GUARNIERI BODIES Meaning and
Definition
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Guarnieri bodies are microscopic structures commonly found in cells infected with a specific type of virus known as cytomegalovirus (CMV). Specifically, Guarnieri bodies are inclusion bodies, which are dense collections of viral particles and other cellular components that form inside the host cell during the viral replication process. These bodies were named after the Italian pathologist Ettore Guarnieri, who first described them in 1904.
The presence of Guarnieri bodies within the cell cytoplasm is considered pathognomonic for CMV infection, meaning that their detection is highly indicative of the disease. These bodies typically appear as dark, rounded structures when viewed under a microscope.
Guarnieri bodies consist of a mixture of viral proteins, nucleic acids, and granular materials that are products of viral replication and packaging. They are formed as a result of the virus taking over the host cell's machinery to produce new viral components.
The detection of Guarnieri bodies in clinical specimens, such as tissue biopsies or blood samples, is of great diagnostic value and can aid in confirming a CMV infection. In addition to their diagnostic significance, these bodies also play a role in understanding the pathogenesis of CMV as well as the host immune response to the infection.
Overall, Guarnieri bodies are distinct structural elements that serve as reliable markers of CMV infection, providing valuable insights into both diagnosis and research into this viral disease.
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Cytoryctes vaccinae, vaccine bodies found in the cornea of rabbits inoculated with vaccine lymph.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
Common Misspellings for GUARNIERI BODIES
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Etymology of GUARNIERI BODIES
The term "Guarnieri bodies" is named after Dr. Enrico Guarnieri, an Italian pathologist who first described these structures. Dr. Guarnieri discovered these abnormal inclusions in the cells of patients with certain viral infections, particularly viral myocarditis (inflammation of the heart muscle) caused by Coxsackie B virus. These inclusions were named after him to honor his contributions to the field of pathology.
Similar spelling words for GUARNIERI BODIES
